MIF20 significantly reduces cardiac infarction in rodents undergoing cardiac ischemia-reperfusion injury.


MIF20 is a small molecule that binds to MIF to specifically augment its affinity to the receptor CD74. By enhancing this binding, this 1,2,3-triazole compund enhances the activation of AMPK and other mediators. This signaling changes the cells metabolically and transcriptionally to enhance survival following ischemia and reperfusion.